Loss of myeloid differentiation protein 1 promotes atrial fibrillation in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Myeloid differentiation protein 1 (MD1) is expressed in the mammalian heart and exerts an anti-arrhythmic effect. Atrial fibrillation (AF) is closely related to heart failure with preserved ejection fraction (HFpEF). The potential impact of MD1 on AF vulnerability in an HFpEF model is not clear.

Methods and results

MD1 knock-out and wild-type (WT) mice were subjected to uninephrectomy and continuous saline or d-aldosterone infusion and given 1% sodium chloride drinking water for 4 weeks. Echocardiographic and haemodynamic measurements, electrophysiological studies, Masson staining, and molecular analysis were performed. Aldosterone-infused WT mice develop HFpEF with left ventricular hypertrophy, moderate hypertension, pulmonary congestion, and diastolic dysfunction. Ald

SUBMITTER: Shuai W 

PROVIDER: S-EPMC7160510 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature