Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report.

ABSTRACT: A key challenge in systematically incorporating mechanistic data into human health assessments is that, compared to studies of apical health endpoints, these data are both more abundant (mechanistic studies routinely outnumber other studies by several orders of magnitude) and more heterogeneous (e.g. different species, test system, tissue, cell type, exposure paradigm, or specific assays performed). A structured decision-making process for organizing, integrating, and weighing mechanistic DNT data for use in human health risk assessments will improve the consistency and efficiency of such evaluations. At the Developmental Neurotoxicology Society (DNTS) 2016 annual meeting, a symposium was held to address the application of existing organizing principles and frameworks for evaluation of mec

SUBMITTER: Carlson LM 

PROVIDER: S-EPMC7160758 | biostudies-literature | 2020 Mar - Apr

REPOSITORIES: biostudies-literature