Theoretical Study on the Antioxidant Activity of Natural Depsidones.

ABSTRACT: Depsidones are secondary metabolites in lichens with a range of potential health benefits. Among others, these compounds are believed to exhibit high hydroxyl radical and superoxide scavenging abilities, warranting a detailed investigation of their antioxidant properties. In this study, the radical scavenging activity of natural depsidones from Ramalina lichenized fungi was investigated in silico. Calculations of the thermodynamic parameters suggested that the main radical scavenging pathway follows the formal hydrogen transfer (FHT) mechanism; however, unexpectedly low rate constants were found in the CH₃OO^• scavenging reaction. Establishing that the depsidones are mostly ionized in an aqueous environment suggested that the single-electron transfer (SET) mecha

SUBMITTER: Bay MV 

PROVIDER: S-EPMC7160836 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature