Analysis of local genome rearrangement improves resolution of ancestral genomic maps in plants.

ABSTRACT:

Background

Computationally inferred ancestral genomes play an important role in many areas of genome research. We present an improved workflow for the reconstruction from highly diverged genomes such as those of plants.

Results

Our work relies on an established workflow in the reconstruction of ancestral plants, but improves several steps of this process. Instead of using gene annotations for inferring the genome content of the ancestral sequence, we identify genomic markers through a process called genome segmentation. This enables us to reconstruct the ancestral genome from hundreds of thousands of markers rather than the tens of thousands of annotated genes. We also introduce the concept of local genome rearrangement, through which we refine syntenic blocks before they ar

SUBMITTER: Rubert DP 

PROVIDER: S-EPMC7160886 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature