Comparing copy-number profiles under multi-copy amplifications and deletions.

ABSTRACT:

Background

During cancer progression, malignant cells accumulate somatic mutations that can lead to genetic aberrations. In particular, evolutionary events akin to segmental duplications or deletions can alter the copy-number profile (CNP) of a set of genes in a genome. Our aim is to compute the evolutionary distance between two cells for which only CNPs are known. This asks for the minimum number of segmental amplifications and deletions to turn one CNP into another. This was recently formalized into a model where each event is assumed to alter a copy-number by 1 or -1, even though these events can affect large portions of a chromosome.

Results

We propose a general cost framework where an event can modify the copy-number of a gene by larger amounts. We show that any cost sc

SUBMITTER: Cordonnier G 

PROVIDER: S-EPMC7160889 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature