Different expression levels of interleukin-35 in asthma phenotypes.

ABSTRACT:

Background

Interleukin (IL)-35 is a newly discovered inhibitory cytokine which is produced by regulatory B and T lymphocytes and belongs to the IL-12 family. It plays a suppressive role in human inflammatory diseases; however, its role in asthma phenotypes is unclear. Our study focuses on the sputum IL-35 level in patients and investigates different airway inflammation capacities of sputum IL-35 in patients with different asthma phenotypes.

Objective

We aimed to determine the sputum IL-35 levels in asthmatic patients with clinical remission phenotypes and control subjects and to investigate possible correlations among lung function, age, sex, fractional exhaled nitric oxide (FeNO), and smoking history in these phenotypes.

Methods

Sputum samples were collected from pat

SUBMITTER: Li W 

PROVIDER: S-EPMC7160921 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature