Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model.

ABSTRACT:

Background

Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell line can be useful for gastric cancer researchers. In this article, we aimed to characterize the diffuse gastric cancer cells with MRI and transcriptomic data. We hypothesized that gene expression pattern is associated with the phenotype of the cells and that the heterogeneous enhancement pattern and the high tumorigenicity of SNU484 can be modulated by the perturbation of the highly expressed gene.

Methods

We evaluated the 9.4 T magnetic resonance imaging and transcriptomic data of the orthotopic mice models from diffuse gastric cancer cells such as SNU484,

SUBMITTER: Yoon SJ 

PROVIDER: S-EPMC7160933 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature