Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery.

ABSTRACT:

Background

The pathophysiology of septic acute kidney injury is inadequately understood. Recently, subphenotypes for sepsis and AKI have been derived. The objective of this study was to assess whether a combination of comorbidities, baseline clinical data, and biomarkers could classify meaningful subphenotypes in septic AKI with different outcomes.

Methods

We performed a post hoc analysis of the prospective Finnish Acute Kidney Injury (FINNAKI) study cohort. We included patients admitted with sepsis and acute kidney injury during the first 48 h from admission to intensive care (according to Kidney Disease Improving Global Outcome criteria). Primary outcomes were 90-day mortality and renal recovery on day 5. We performed latent class analysis using 30 variables obtained on ad

SUBMITTER: Wiersema R 

PROVIDER: S-EPMC7161019 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature