Self-Inclusion and Dissociation of a Bridging β-Cyclodextrin Triplet.

ABSTRACT: To understand the self-inclusion and the dissociation in a branched β-cyclodextrin (CD) system, we designed and synthesized a β-CD trimer in which each CD group is connected to one of bridging arms of a planar triphenylbenzene core through a CuAAC click reaction. Only one rather than two or all of the three host CDs was demonstrated to be in a self-including state in water, while no self-inclusion was observed to occur in dimethylsulfoxide (DMSO) via the characterization of ¹H and NOESY NMR spectra. The configuration structures of the CD groups in the self-included state were evaluated, and the dissociation to free state in water was investigated under various conditions like heating, increased acidity, and discharging versus the addition of competitive guests. While raised temp

SUBMITTER: Gao B 

PROVIDER: S-EPMC7161068 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature