Assessing breed integrity of Gottingen Minipigs.

ABSTRACT:

Background

Göttingen Minipigs (GMP) is the smallest commercially available minipig breed under a controlled breeding scheme and is globally bred in five isolated colonies. The genetic isolation harbors the risk of stratification which might compromise the identity of the breed and its usability as an animal model for biomedical and human disease. We conducted whole genome re-sequencing of two DNA-pools per colony to assess genomic differentiation within and between colonies. We added publicly available samples from 13 various pig breeds and discovered overall about 32 M loci, ~ 16 M. thereof variable in GMPs. Individual samples were virtually pooled breed-wise. F_ST between virtual and DNA pools, a phylogenetic tree, principal component analysis (PCA) and evaluation of fu

SUBMITTER: Reimer C 

PROVIDER: S-EPMC7161115 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature