Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma.

ABSTRACT:

Background

CELSR2 is postulated to be a receptor involved in contact-mediated communication; however, the specific function of this particular member has not been determined in hepatocellular carcinoma (HCC).

Methods

Here, we explored the expression and function of CELSR2 in HCC patients through data mining and examined the results using clinical samples and in vitro experiments.

Results

It was found that CELSR2 mRNA and protein expression levels were significantly higher in cancerous tissue than in normal tissue. The increased mRNA expression of CELSR2 was significantly associated with overall survival (OS) in HCC patients. Moreover, the genetic alteration rate of CELSR2 gene in HCC can reach 8%, and these alterations would deeply influence its neighboring genes, the

SUBMITTER: Xu M 

PROVIDER: S-EPMC7161135 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature