Gastrointestinal peptides in children before and after hematopoietic stem cell transplantation.

ABSTRACT:

Background

Gastrointestinal tract function and it's integrity are controlled by a number of peptides whose secretion is influenced by severe inflammation. In stomach the main regulatory peptide is ghrelin. For upper small intestine cholecystokinin and lower small intestine glucagon-like peptide- 1 are secreted, while fibroblast growth factor-21 is secreted by several organs, including the liver, pancreas, and adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this peptides.

Methods

The aim of the study was to determine fasting plasma concentrations of ghrelin, cholecystokinin, glucagon- like peptide-1, and fibroblast growth factor-21, and their gene expressions, before and 6 months after hematopoietic stem cell tr

SUBMITTER: Skoczen S 

PROVIDER: S-EPMC7161205 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature