Treatment-related changes in neuroendocrine tumors as assessed by textural features derived from ⁶⁸Ga-DOTATOC PET/MRI with simultaneous acquisition of apparent diffusion coefficient.

ABSTRACT:

Background

Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTRs), which is the molecular basis for ⁶⁸Ga-DOTATOC positron-emission tomography (PET) and radiopeptide therapy (PRRT). However, SSTR expression fluctuates and can be subject to treatment-related changes. The aim of this retrospective study was to assess, which changes in PET and apparent diffusion coefficient (ADC) occur for different treatments and if pre-therapeutic ⁶⁸Ga-DOTATOC-PET/MRI was able to predict treatment response to PRRT.

Methods

Patients with histopathologically confirmed NET, at least one liver metastasis > 1 cm and at least two ⁶⁸Ga-DOTATOC-PET/MRI including ADC maps were eligible. ⁶⁸Ga-DOTATOC-PET/MRI of up to 5 liver lesions

SUBMITTER: Weber M 

PROVIDER: S-EPMC7161278 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature