Intracranial pressure elevation alters CSF clearance pathways.

ABSTRACT: BACKGROUND:Infusion testing is a common procedure to determine whether shunting will be beneficial in patients with normal pressure hydrocephalus. The method has a well-developed theoretical foundation and corresponding mathematical models that describe the CSF circulation from the choroid plexus to the arachnoid granulations. Here, we investigate to what extent the proposed glymphatic or paravascular pathway (or similar pathways) modifies the results of the traditional mathematical models. METHODS:We used a compartment model to estimate pressure in the subarachnoid space and the paravascular spaces. For the arachnoid granulations, the cribriform plate and the glymphatic circulation, resistances were calculated and used to estimate pressure and flow before and during an infusion test. Fina

SUBMITTER: Vinje V 

PROVIDER: S-EPMC7161287 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature