RNAconTest: comparing tools for noncoding RNA multiple sequence alignment based on structural consistency.

ABSTRACT: The importance of noncoding RNA sequences has become increasingly clear over the past decade. New RNA families are often detected and analyzed using comparative methods based on multiple sequence alignments. Accordingly, a number of programs have been developed for aligning and deriving secondary structures from sets of RNA sequences. Yet, the best tools for these tasks remain unclear because existing benchmarks contain too few sequences belonging to only a small number of RNA families. RNAconTest (RNA consistency test) is a new benchmarking approach relying on the observation that secondary structure is often conserved across highly divergent RNA sequences from the same family. RNAconTest scores multiple sequence alignments based on the level of consistency among known secondary structure

SUBMITTER: Wright ES 

PROVIDER: S-EPMC7161358 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature