Identifying Hypoperfusion in Moyamoya Disease With Arterial Spin Labeling and an [¹⁵O]-Water Positron Emission Tomography/Magnetic Resonance Imaging Normative Database.

ABSTRACT: Background and Purpose- Noninvasive imaging of brain perfusion has the potential to elucidate pathophysiological mechanisms underlying Moyamoya disease and enable clinical imaging of cerebral blood flow (CBF) to select revascularization therapies for patients. We used hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) technology to characterize the distribution of hypoperfusion in Moyamoya disease and its relationship to vessel stenosis severity, through comparisons with a normative perfusion database of healthy controls. Methods- To image CBF, we acquired [¹⁵O]-water PET as a reference and simultaneously acquired arterial spin labeling (ASL) MRI scans in 20 Moyamoya patients and 15 age-matched, healthy controls on a PET/MRI scanner. The ASL MRI scans inc

SUBMITTER: Fan AP 

PROVIDER: S-EPMC7161423 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature