Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?

ABSTRACT:

Objective

To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.

Design

Review of English publications in PubMed and Embase to April 6, 2020.

Method(s)

Articles were screened for reports including coronavirus, reproduction, pathophysiology, and pregnancy.

Intervention(s)

None.

Main outcome measure(s)

Reproductive outcomes, effects on gametes, pregnancy outcomes, and neonatal complications.

Result(s)

Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin-converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophi

SUBMITTER: Segars J 

PROVIDER: S-EPMC7161522 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature