Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects.

ABSTRACT:

Background and purpose

Hypertension is associated with gut dysbiosis. Here we have evaluated the effects of the angiotensin receptor antagonist losartan on gut microbiota in spontaneously hypertensive rats (SHR) to assess their contribution to its antihypertensive effects.

Experimental approach

Twenty-week-old Wistar Kyoto rats (WKY) and SHR were treated with losartan for 5 weeks (SHR-losartan). Faecal microbiota transplantation (FMT) was performed from donor SHR-losartan group to recipient untreated-SHR. Blood pressure (BP) was measured using tail-cuff plethysmography. Composition of the gut microbiota was assessed by amplification of the V3-V4 region of 16S rRNA gene. T cells were analysed in gut/aorta by flow cytometry.

Key results

Faeces from SHR showed gut dysbio

SUBMITTER: Robles-Vera I 

PROVIDER: S-EPMC7161554 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature