Donecopride, a Swiss army knife with potential against Alzheimer's disease.

ABSTRACT:

Background and purpose

We recently identified donecopride as a pleiotropic compound able to inhibit AChE and to activate 5-HT₄ receptors. Here, we have assessed the potential therapeutic effects of donecopride in treating Alzheimer's disease (AD).

Experimental approach

We used two in vivo animal models of AD, transgenic 5XFAD mice and mice exposed to soluble amyloid-β peptides and, in vitro, primary cultures of rat hippocampal neurons. Pro-cognitive and anti-amnesic effects were evaluated with novel object recognition, Y-maze, and Morris water maze tests. Amyloid load in mouse brain was measured ex vivo and effects of soluble amyloid-β peptides on neuronal survival and neurite formation determined in vitro.

Key results

In vivo, chronic (3 months) administra

SUBMITTER: Rochais C 

PROVIDER: S-EPMC7161555 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature