Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis.

ABSTRACT:

Background and purpose

Gout arthritis, which is provoked by monosodium urate (MSU) crystal accumulation in the joint and periarticular tissues, induces severe pain and affects quality of life of the patients. Eucalyptol (1,8-cineol), the principal component in the essential oils of eucalyptus leaves, is known to possess anti-inflammatory and analgesic properties. We aimed to examine the therapeutic effects of eucalyptol on gout arthritis and related mechanisms.

Experimental approach

A mouse model of gout arthritis was established via MSU injection into the ankle joint. Ankle oedema, mechanical allodynia, neutrophil infiltration, oxidative stress, NLRP3 inflammasome, and TRPV1 expression were examined.

Key results

Eucalyptol attenuated MSU-induced mechanical allodynia

SUBMITTER: Yin C 

PROVIDER: S-EPMC7161556 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature