The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein.

ABSTRACT: Natural products remain an important source of drug leads covering unique chemical space and providing significant therapeutic value for the control of cancer and infectious diseases resistant to current drugs. Here, we determined the antiproliferative activity of a natural product manzamine A (1) from an Indo-Pacific sponge following various in vitro cellular assays targeting cervical cancer (C33A, HeLa, SiHa, and CaSki). Our data demonstrated the antiproliferative effects of 1 at relatively low and non-cytotoxic concentrations (up to 4 μM). Mechanistic investigations confirmed that 1 blocked cell cycle progression in SiHa and CaSki cells at G1/S phase and regulated cell cycle-related genes, including restoration of p21 and p53 expression. In apoptotic assays, HeLa ce

SUBMITTER: Karan D 

PROVIDER: S-EPMC7161578 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature