Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis.

ABSTRACT:

Background

Recurrent pregnancy loss (RPL) occurs in 1-3% of all couples trying to conceive. No consensus exists regarding when to perform testing for risk factors in couples with RPL. Some guidelines recommend testing if a patient has had two pregnancy losses whereas others advise to test after three losses.

Objective and rationale

The aim of this systematic review was to evaluate the current evidence on the prevalence of abnormal test results for RPL amongst patients with two versus three or more pregnancy losses. We also aimed to contribute to the debate regarding whether the investigations for RPL should take place after two or three or more pregnancy losses.

Search methods

Relevant studies were identified by a systematic search in OVID Medline and EMBASE from ince

SUBMITTER: van Dijk MM 

PROVIDER: S-EPMC7161667 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature