Fetal exposure to herpesviruses may be associated with pregnancy-induced hypertensive disorders and preterm birth in a Caucasian population.

ABSTRACT:

Objective

To investigate the role of fetal viral infection in the development of a range of adverse pregnancy outcomes (APOs), including pregnancy-induced hypertensive disorders (PIHD), antepartum haemorrhage (APH), birthweight <10th percentile (small for gestational age, SGA) and preterm birth (PTB).

Design

Population-based case-control study.

Setting

Laboratory-based study.

Population

The newborn screening cards of 717 adverse pregnancy cases and 609 controls.

Methods

Newborn screening cards were tested for RNA from enteroviruses and DNA from herpesviruses using polymerase chain reaction (PCR). The herpesviruses were detected using two PCRs, one detecting nucleic acids from herpes simplex virus (HSV)-1, HSV-2, Epstein-Barr virus (EBV), cytomegalovirus

SUBMITTER: Gibson CS 

PROVIDER: S-EPMC7161814 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature