CLCA2 expression is associated with survival among African American women with triple negative breast cancer.

ABSTRACT:

Purpose

Black/African American (AA) women are twice as likely to be diagnosed with triple negative breast cancer (TNBC) compared to whites, an aggressive breast cancer subtype associated with poor prognosis. There are no routinely used targeted clinical therapies for TNBC; thus there is a clear need to identify prognostic markers and potential therapeutic targets.

Methods

We evaluated expression of 27,016 genes in 155 treatment-naïve TN tumors from AA women in Detroit. Associations with survival were evaluated using Cox proportional hazards models adjusting for stage and age at diagnosis, and p-values were corrected using a false discovery rate. Our validation sample consisted of 494 TN tumors using four publically available data sets. Meta-analyses were performed using summ

SUBMITTER: Purrington KS 

PROVIDER: S-EPMC7161959 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature