Analysis of viral infection and biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease.

ABSTRACT:

Objective

To investigate viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in Shanghai, and to analyze the clinical characteristics and biomarkers in viral infection.

Methods

This study included all consecutive patients who were admitted for a diagnosis of AECOPD during June 2013 to May 2015. Thirty-one stable COPD patients and 31 healthy controls were also recruited. Oropharyngeal samples were assessed, PCR for respiratory viruses were performed. Patients were divided into AECOPD virus-positive (+) group and AECOPD virus-negative (-) group according to viral detection. Luminex was used to detect the concentrations of inflammatory cytokines in the serum.

Results

A total of 264 patients were included with a mean age o

SUBMITTER: Yin T 

PROVIDER: S-EPMC7162408 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature