Impact of growth factor content on proliferation of mesenchymal stromal cells derived from adipose tissue.

ABSTRACT: Autologous adipose tissue (AT) transfer has gained widespread acceptance and is used for a broad variety of regenerative clinical indications. It is assumed that the successful outcome of AT transfer essentially depends on the amount of autocrine-generated growth factors (GF). It is supposed that several GF enhance and improve the anatomic and functional integration of the transplanted AT grafts at the site of implantation. In the present study we have investigated for the first time the correlation between the concentration of GF of freshly isolated AT and the proliferation and migration capacity of mesenchymal stroma cells (MSCs) derived from the respective AT sample. We here show that the proliferation and migration capacity of MSCs strongly depends on the GF content of the AT the cells

SUBMITTER: Franz KC 

PROVIDER: S-EPMC7162516 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature