Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis.

ABSTRACT: Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. It is the third most common human mycobacterial disease after tuberculosis (TB) and leprosy. The available methods for detection of the bacilli in lesions are microscopic detection, isolation and cultivation of the bacterium, histopathology, and polymerase chain reaction (PCR). These methods, although approved by the World Health Organization (WHO), have infrastructural and resource challenges in medical centres and cell-mediated immunity (CMI) and/or serology-based tests have been suggested as easier and more appropriate for accurate assessment of the disease, especially in remote or underdeveloped areas. This study systematically reviewed and conducted a meta-analysis for all research aim

SUBMITTER: Avumegah MS 

PROVIDER: S-EPMC7162525 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature