Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation.

ABSTRACT: Interhomolog crossovers (COs) are a prerequisite for achieving accurate chromosome segregation during meiosis [1, 2]. COs are not randomly positioned, occurring at distinct genomic intervals during meiosis in all species examined [3-10]. The role of CO position as a major determinant of accurate chromosome segregation has not been previously directly analyzed in a metazoan. Here, we use spo-11 mutants, which lack endogenous DNA double-strand breaks (DSBs), to induce a single DSB by Mos1 transposon excision at defined chromosomal locations in the C. elegans germline and show that the position of the resulting CO directly affects the formation of distinct chromosome subdomains during meiotic chromosome remodeling. CO formation in the typically CO-deprived center region of autosomes leads to

SUBMITTER: Altendorfer E 

PROVIDER: S-EPMC7162695 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature