CD4⁺ /CD8⁺ T-cell ratio correlates with the graft fate in pig-to-non-human primate islet xenotransplantation.

ABSTRACT:

Background

Xenogeneic islet transplantation using porcine pancreata has been a promising option for substituting human islet transplantation. Moreover, recent advances in pre-clinical results have put islet xenotransplantation closer to the possibility of clinical application. While preparing for the era of clinical xenotransplantation, developing non-invasive immune monitoring method which could predict the graft fate could benefit the patient. However, there are few reports showing predictive immune parameters associated with the fate of the graft in islet xenotransplantation.

Methods

The absolute number and ratio of T-cell subsets have been measured via flow cytometry from the peripheral blood of 16 rhesus monkeys before and after porcine islet xenotransplantation. The co

SUBMITTER: Chung H 

PROVIDER: S-EPMC7162713 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature