Replicating predictive serum correlates of greater translocator protein distribution volume in brain.

ABSTRACT: Greater activation of glia, a key component of neuroinflammation, is an important process to target in neuropsychiatric illnesses. However, the magnitude of gliosis varies across cases so low-cost predictors are needed to stratify subjects for clinical trials. Here, several such blood serum measures were assessed in relation to TSPO V_T, an index of translocator protein density, measured with positron emission tomography. Blood serum concentration of several products known to be synthesized by activated microglia (and to some extent astroglia) [prostaglandin E₂ (PGE₂), prostaglandin F₂ alpha (PGF_2α), and tumor necrosis factor alpha (TNF_α)], controlled by an index of peripheral inflammation [C-reactive protein (CRP)] and TSPO

SUBMITTER: Attwells S 

PROVIDER: S-EPMC7162884 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature