Short Report: Circulating microRNAs are associated with incident diabetes over 10 years in Japanese Americans.

ABSTRACT: Epigenetic changes precede the development of diabetes by many years, providing clues to its pathogenesis. We explored whether the epigenetic markers, circulating microRNAs (miRNAs), were associated with incident diabetes in Japanese Americans. We conducted a pilot study (n = 10) using plasma from age- and sex-matched participants who did or did not develop diabetes in the Japanese American Community Diabetes Study, an observational study of diabetes risk factors. Extraction and high-throughput sequencing of miRNAs were performed using samples collected at baseline. Regression models were fit comparing circulating miRNAs (N = 1640) among individuals who did or did not develop incident diabetes at 10-year follow-up. Participants averaged 51.7 years of age at baseline; 60% were male. We iden

SUBMITTER: Wander PL 

PROVIDER: S-EPMC7162904 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature