Cigarette smoking induces human CCR6⁺Th17 lymphocytes senescence and VEGF-A secretion.

ABSTRACT: Chronic exposure to environmental pollutants is often associated with systemic inflammation. As such, cigarette smoking contributes to inflammation and lung diseases by inducing senescence of pulmonary cells such as pneumocytes, fibroblasts, and endothelial cells. Yet, how smoking worsens evolution of chronic inflammatory disorders associated with Th17 lymphocytes, such as rheumatoid arthritis, psoriasis, Crohn's disease, and multiple sclerosis, is largely unknown. Results from human studies show an increase in inflammatory CD4⁺ Th17 lymphocytes at blood- and pulmonary level in smokers. The aim of the study was to evaluate the sensitivity of CD4⁺ Th17 lymphocytes to cigarette smoke-induced senescence. Mucosa-homing CCR6⁺ Th17- were compared to CCR6^neg<

SUBMITTER: Baskara I 

PROVIDER: S-EPMC7162978 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature