Genome diversity and evolutionary characteristics of clinical isolates of Bordetella pertussis circulating in Iran.

ABSTRACT:

Background and objectives

The re-emergence of pertussis still is being reported all over the world. Pathogen adaptation and antigenic divergence of circulating isolates from vaccine strains are the main reasons of infection resurgence. Waning immunity is also an important factor contributing to resurgence of pertussis.

Materials and methods

The genetic diversity and evolutionary characteristics of circulating Iranian isolates of Bordetella pertussis during February 2015 to October 2018 was investigated by pulsed-field gel electrophoresis (PFGE) and subsequently ptxA, ptxP and fim3 alleles were characterized. The next generation genome sequencing was then used to compare the genomics of ptxP1 and ptxP3 of selected isolates from PFGE dendrogr

SUBMITTER: Saedi S 

PROVIDER: S-EPMC7163038 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature