Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley Rats.

ABSTRACT:

Background

Despite extensive studies, there are still no clinically available neuroprotective treatments for traumatic brain injury.

Objectives

In previous studies we demonstrated beneficial treatment effects of polyarginine peptides R18 (18-mer of arginine; 300 nmol/kg) and R18D (18-mer of D-arginine; 1000 nmol/kg) in a rat model of impact-acceleration closed-head injury.

Methods

We examined the efficacy of R18D when intravenously administered at a low (100 nmol/kg) and high (1000 nmol/kg) dose, 30 minutes after a closed-head injury in male Sprague-Dawley rats.

Results

At postinjury day 3, treatment with R18D at the high dose significantly reduced axonal injury (P = 0.044), whereas the low-dose treatment of R18D showed a trend for reduced axonal injury.

SUBMITTER: Chiu LS 

PROVIDER: S-EPMC7163064 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature