Postoperative intensity-modulated radiation therapy reduces local recurrence and improves overall survival in III-N2 non-small-cell lung cancer: A single-center, retrospective study.

ABSTRACT:

Purpose

To determine the postoperative effects of radiotherapy (PORT) on the local recurrence-free survival (LRFS) and overall survival (OS) of stage III-N2 non-small-cell lung cancer (NSCLC).

Materials and methods

183 patients with resected stage III-pN2 NSCLC from Hunan Cancer Hospital between 2013 and 2016 were divided into two groups for postoperative chemotherapy (POCT) (n = 105) or combination chemotherapy and radiotherapy (POCRT) (n = 78). The LRFS and OS were compared and the factors affecting local recurrence were illustrated in these two groups. The sites of failure based on the lobe of the primary tumor in two groups were described.

Results

PORT leads to a strikingly lower risk for local recurrence and brought superior OS benefit. For different pN2 Subclass

SUBMITTER: Wei W 

PROVIDER: S-EPMC7163098 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature