Sequential boost of intensity-modulated radiotherapy with chemotherapy for inoperable esophageal squamous cell carcinoma: A prospective phase II study.

ABSTRACT:

Purpose

This prospective phase II study aimed to determine the efficacy and tolerability of sequential boost of intensity-modulated radiation therapy (IMRT) with chemotherapy for patients with inoperable esophageal squamous cell carcinoma (ESCC).

Methods

Patients with histologically or cytologically proven inoperable ESCC were enrolled in this study (ChiCTR-OIC-17010485). A larger target volume for subclinical lesion was irradiated with 50 Gy, and then, a smaller target volume only including gross tumor was boosted to 66 Gy. The fraction dose was 2 Gy, and no elective node was irradiated. Concurrent and consolidation chemotherapy of fluorouracil (600 mg/m² , days 1-3) plus cisplatin (25 mg/m² , days 1-3) was administered every 4 weeks, for 4 cycles in t

SUBMITTER: Fan XW 

PROVIDER: S-EPMC7163105 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature