Diversity and Function of Maternal HIV-1-Specific Antibodies at the Time of Vertical Transmission.

ABSTRACT: Infants of HIV-positive mothers can acquire HIV infection by various routes, but even in the absence of antiviral treatment, the majority of these infants do not become infected. There is evidence that maternal antibodies provide some protection from infection, but gestational maternal antibodies have not yet been characterized in detail. One of the most studied vertically infected infants is BG505, as the virus from this infant yielded an Envelope protein that was successfully developed as a stable trimer. Here, we isolated and characterized 39 HIV-specific neutralizing monoclonal antibodies (nAbs) from MG505, the mother of BG505, at a time point just prior to vertical transmission. These nAbs belonged to 21 clonal families and employed a variety of VH genes. Many were specific for the HI

SUBMITTER: Doepker LE 

PROVIDER: S-EPMC7163126 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature