CCR9 Promotes Migration and Invasion of Lung Adenocarcinoma Cancer Stem Cells.

ABSTRACT: Aim: CC chemokine receptor 9 (CCR9) interacts with its exclusive ligand CCL25, resulting in promoting tumor progression and metastasis. However, the effect and mechanisms of CCR9 on lung adenocarcinoma distant metastasis remain largely unknown. To preliminary clarify the underlying mechanisms, we investigate the correlation between CCR9 and ALDH1A1⁺cancer stem cells (CSCs), as well as the effect of CCR9 on the migration and invasion of CSCs. Methods: Immunohistochemistry was performed to detect the expression of CCR9 in lung adenocarcinoma tissues. The correlations of CCR9 with distant metastasis and overall survival were investigated. Serial paraffin-embedded tissue blocks were used to detect ALDH1A1⁺CSCs expression. The correlations between CCR9 expres

SUBMITTER: Lu L 

PROVIDER: S-EPMC7163367 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature