Placental transporter-mediated drug interactions and offspring congenital anomalies.

ABSTRACT:

Aims

P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are efflux transporters expressed in the placenta, limiting their substrates from reaching the foetus. Our aim was to investigate if concomitant prenatal exposure to several substrates or inhibitors of these transporters increases the risk of congenital anomalies.

Methods

The national Drugs and Pregnancy database, years 1996-2014, was utilized in this population-based birth cohort study. In the database, the Medical Birth Register, the Register on Induced Abortions, the Malformation register and the Register on Reimbursed Drug Purchases have been linked. The University of Washington Metabolism and Transport Drug Interaction Database was used to identify substrates and inhibitors of P-gp and BCRP. We inclu

SUBMITTER: Ellfolk M 

PROVIDER: S-EPMC7163376 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature