PH responsive superporogen combined with PDT based on poly Ce6 ionic liquid grafted on SiO₂ for combating MRSA biofilm infection.

ABSTRACT: Background: Biofilm infection caused by multidrug-resistant bacteria is difficult to eradicate by conventional therapies. Photodynamic therapy (PDT) is an effective antibacterial method for fighting against biofilm infection. However, the blocked photosensitizers outside of biofilm greatly limit the efficacy of PDT. Methods: Herein, a novel acid-responsive superporogen and photosensitizer (SiO₂-P_Ce6-IL) was developed. Because of the protonation of the photosensitizer and the high binding energy of the polyionic liquid, SiO₂-P_Ce6-IL changed to positive SiO₂-P_IL ⁺ in an acidic microenvironment of biofilm infection. SiO₂-P_IL ⁺ could combine with negatively charged extrac

SUBMITTER: Wang C 

PROVIDER: S-EPMC7163436 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature