Imaging of tumor colonization by Escherichia coli using ¹⁸F-FDS PET.

ABSTRACT: Tumor-targeting bacteria have been actively investigated as a new therapeutic tool for solid tumors. However, in vivo imaging of tumor-targeting bacteria has not been fully established. ¹⁸F-fluorodeoxysorbitol (FDS) positron emission tomography (PET) is known to be capable of imaging Gram-negative Enterobacteriaceae infection. In the present study, we aimed to validate the use of ¹⁸F-FDS PET for visualization of the colonization and proliferation of tumor-targeting Escherichia coli (E. coli) MG1655 in mouse tumor models. Methods: E. coli (5 × 10⁷ colony forming unit) were injected intravenously into BALB/c mice bearing mouse colon cancer (CT26). Before and 1, 3, and 5 days after the bacterial injection, PET imaging was per

SUBMITTER: Kang SR 

PROVIDER: S-EPMC7163454 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature