Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation.

ABSTRACT: Purpose: Osteoporosis is more likely to cause serious complications after joint replacement, mainly due to physiological defects of endogenous osteogenic cells and the pathological osteoclast activity. It is a feasible solution to design a prosthetic surface interface that specifically addresses this troublesome situation. Methods: A novel "three-dimensional (3D) inorganic-organic supramolecular bioactive interface" was constructed consisting of stiff 3D printing porous metal scaffold and soft multifunctional, self-healable, injectable, and biodegradable supramolecular polysaccharide hydrogel. Apart from mimicking the bone extracellular matrix, the bioactive interface could also encapsulate bioactive substances, namely bone marrow mesenchymal stem cells (BMSCs) and bone morph

SUBMITTER: Bai H 

PROVIDER: S-EPMC7163459 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature