Inferring infection hazard in wildlife populations by linking data across individual and population scales.

ABSTRACT: Our ability to infer unobservable disease-dynamic processes such as force of infection (infection hazard for susceptible hosts) has transformed our understanding of disease transmission mechanisms and capacity to predict disease dynamics. Conventional methods for inferring FOI estimate a time-averaged value and are based on population-level processes. Because many pathogens exhibit epidemic cycling and FOI is the result of processes acting across the scales of individuals and populations, a flexible framework that extends to epidemic dynamics and links within-host processes to FOI is needed. Specifically, within-host antibody kinetics in wildlife hosts can be short-lived and produce patterns that are repeatable across individuals, suggesting individual-level antibody concentrations could b

SUBMITTER: Pepin KM 

PROVIDER: S-EPMC7163542 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature