Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

ABSTRACT:

Background

Human epidermal growth factor receptor (EGFR) is an oncogenic gene and one of top targets of precision therapy in lung cancer with EGFR mutations. Although there are many reports for some individual cancers, comprehensive profiling of EGFR mutations, overexpression, amplification, DNA methylation, and their clinical associations across many different cancers simultaneously was not available. This study aimed to fill the gap and provide insights to the alteration spectrum of EGFR and its therapeutic and prognostic implications.

Methods

The Cancer Genome Atlas (TCGA) datasets for 32 cancer types involving 11,314 patients were analyzed for alterations (mutations and amplification/deletion), abnormal expression and DNA methylation in EGFR gene. Mutation frequency, gen

SUBMITTER: Liu H 

PROVIDER: S-EPMC7163653 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature