Investigation of the gene co-expression network and hub genes associated with acute mountain sickness.

ABSTRACT:

Background

Acute mountain sickness has become a heavily researched topic in recent years. However, the genetic mechanism and effects have not been elucidated. Our goal is to construct a gene co-expression network to identify the key modules and hub genes associated with high altitude hypoxia.

Results

The GSE46480 dataset of rapidly transported healthy adults with acute mountain sickness was selected and analyzed by weighted gene co-expression network analysis (WGCNA) to construct a co-expression network. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the data set were carried out using Database for Annotation Visualization and Integrated Discovery (DAVID), and the hub genes were selected. We found that the turquoise module wa

SUBMITTER: Chang Y 

PROVIDER: S-EPMC7164164 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature