TBL1XR1 mutation predicts poor outcome in primary testicular diffuse large B-cell lymphoma patients.

ABSTRACT: Primary testicular lymphoma (PTL), often appearing as focal masses in the scrotum and epididymides, is the most frequent testicular tumor in aged men. Although MYD88 and CD79B mutations were the most common genetic alterations observed, the gene mutation landscape of PTL remains poorly defined. In this study, we identified 1326 mutations involving 311 genes or regions in 90 PTL patients through next-generation sequencing (NGS). PTL patients with the TBL1XR1 mutation, irrespective of treatment therapy, had an inferior overall survival (OS) than TBL1XR1 WT (wild type) patients (p = 0.045). Moreover, patients with this mutation, treated with a CHOP regimen (CTX 750 mg/m² iv, d1,8 ADM 50 mg/m² iv, d1 VCR 1.4 mg/m² iv, d1 PDN 100 mg/m² po d1-5)

SUBMITTER: Wang X 

PROVIDER: S-EPMC7164167 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature