Microarray data analysis on gene and miRNA expression to identify biomarkers in non-small cell lung cancer.

ABSTRACT:

Background

The aim of this study was to gain further investigation of non-small cell lung cancer (NSCLC) tumorigenesis and identify biomarkers for clinical management of patients through comprehensive bioinformatics analysis.

Methods

miRNA and mRNA microarray datasets were downloaded from GEO (Gene Expression Omnibus) database under the accession number GSE102286 and GSE101929, respectively. Genes and miRNAs with differential expression were identified in NSCLC samples compared with controls, respectively. The interaction between differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRs) was predicted, followed by functional enrichment analysis, and construction of miRNA-gene regulatory network, protein-protein interaction (PPI) network, and competing

SUBMITTER: Jin X 

PROVIDER: S-EPMC7164187 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature