Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain.

ABSTRACT:

Background

Many lines of evidence suggest that accumulation of aggregated alpha-synuclein (αSYN) in the Parkinson's disease (PD) brain causes infiltration of T cells. However, in which ways the stationary brain cells interact with the T cells remain elusive. Here, we identify astrocytes as potential antigen-presenting cells capable of activating T cells in the PD brain. Astrocytes are a major component of the nervous system, and accumulating data indicate that astrocytes can play a central role during PD progression.

Methods

To investigate the role of astrocytes in antigen presentation and T-cell activation in the PD brain, we analyzed post mortem brain tissue from PD patients and controls. Moreover, we studied the capacity of cultured human astrocytes and adult human microg

SUBMITTER: Rostami J 

PROVIDER: S-EPMC7164247 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature