Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti.

ABSTRACT:

Background

Aedes aegypti is a globally distributed vector of human diseases including dengue, yellow fever, chikungunya, and Zika. Pyrethroid insecticides are the primary means of controlling adult A. aegypti populations to suppress arbovirus outbreaks, but resistance to pyrethroid insecticides has become a global problem. Mutations in the voltage-sensitive sodium channel (Vssc) gene are a major mechanism of pyrethroid resistance in A. aegypti. Vssc resistance alleles in A. aegypti commonly have more than one mutation. However, our understanding of the evolutionary dynamics of how alleles with multiple mutations arose is poorly understood.

Methodology/principal findings

We examined the geographic distribution and association between the common Vssc mutations (V410L, S989P, V

SUBMITTER: Fan Y 

PROVIDER: S-EPMC7164583 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature