Estimating the cost of vaccine development against epidemic infectious diseases: a cost minimisation study.

ABSTRACT:

Background

The Coalition for Epidemic Preparedness Innovations was established in 2016, to develop vaccines that can contribute to preparedness for outbreaks of epidemic infectious diseases. Evidence on vaccine development costs for such diseases is scarce. Our goal was to estimate the minimum cost for achieving vaccine research and development preparedness targets in a portfolio of 11 epidemic infectious diseases, accounting for vaccine pipeline constraints and uncertainty in research and development preparedness outcomes.

Methods

We assembled a pipeline of 224 vaccine candidates from preclinical through to phase 2 for 11 priority epidemic infectious diseases. We used a linear regression model to identify drivers of development costs from preclinical through to end of phase

SUBMITTER: Gouglas D 

PROVIDER: S-EPMC7164811 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature